CMA
Our CMAs
Array Science manufactures the highest quality cell culture microarrays (CMAs), suitable for advanced histologic analyses such as immunohistochemistry (IHC) and in situ hybridization (ISH). Applications include assay optimization, validation, daily quality control, inter-laboratory comparisons, and proficiency testing. We produce CMAs from cell pellets supplied by clients or from trusted industry partners.
Our blocks are built with standard core diameters of 1.0mm, 1.5mm, or 2.0mm, and depths up to 15mm. Custom core sizes and cell densities are available upon request.
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FOR RESEARCH USE ONLY
Customizable
Customizable
Customize with number of cores, core diameter and depth, or cell density.
Built with cell cultures provided by you or carefully selected from trusted sources.
Certified
Certified
CMA blocks are quality checked by a board-certified pathologist.
All cell culture identities in a CMA block are recorded and mapped in our custom database for maximum traceability.
High Yield
High Yield
Our blocks are built to be highly uniform in cell density, and as tall as desired.
With careful technique, the blocks can yield up to 100-150 sections per 1mm (cut at 3-4 microns) so you can get the best price per section.
Our CMA Products
Breast Cancer Controls
| Catalog Number | BC-2-1-3-1 | BC-7-1-3-2 |
|---|---|---|
| Description | Breast 2-core IHC and FISH control | HER2Low 7-core IHC and FISH control |
| Core diameter | 1 mm | 1 mm |
| Well depth | 3 mm | 3 mm |
| Estimated yield per block | Up to 450 slides | Up to 450 slides |
| Composition | HER2 is 3+ in one core and 1+ in the other. By FISH, one core is negative core and the other is strongly amplified. ER and PR are positive in one core and negative in the other. ​ This control also shows reactivity for GATA3, GCDFP-15 and Mammaglobin. | Our 7-core HER2 control shows fine incremental increases in HER2 expression, especially in the range of 1+, which is now of increasing clinical importance. This is an excellent control for FISH assays, as well as IHC. |
| Number of cells per core | Approximately 2,000 | Approximately 2,000 |
| Storage conditions | 4°C to 25°C | 4°C to 25°C |
| Use by | Stable for 24 months from date of manufacture | Stable for 24 months from date of manufacture |
| Indication | Research Use Only | Research Use Only |
| Catalog Number | BC-2-1-3-1 | BC-7-1-3-2 |
|---|---|---|
| Description | Breast 2-core IHC and FISH control | HER2Low 7-core IHC and FISH control |
| Core diameter | 1 mm | 1 mm |
| Well depth | 3 mm | 3 mm |
| Estimated yield per block | Up to 450 slides | Up to 450 slides |
| Composition | HER2 is 3+ in one core and 1+ in the other. By FISH, one core is negative core and the other is strongly amplified. ER and PR are positive in one core and negative in the other. ​ This control also shows reactivity for GATA3, GCDFP-15 and Mammaglobin. | Our 7-core HER2 control shows fine incremental increases in HER2 expression, especially in the range of 1+, which is now of increasing clinical importance. This is an excellent control for FISH assays, as well as IHC. |
| Number of cells per core | Approximately 2,000 | Approximately 2,000 |
| Storage conditions | 4°C to 25°C | 4°C to 25°C |
| Use by | Stable for 24 months from date of manufacture | Stable for 24 months from date of manufacture |
| Indication | Research Use Only | Research Use Only |
Mismatch Repair Control
| Catalog Number | MMR-4-1-3-1 |
|---|---|
| Description | Mismatch Repair Control 4-core |
| Core diameter | 1 mm |
| Well depth | 3 mm |
| Estimated yield per block | Up to 450 slides |
| Composition | Specific knockout mutations of mismatch repair (MMR) genes: MLH1, PMS2, MSH2, and MSH6. This is the only IHC control to provide true specificity for these markers. |
| Number of cells per core | Approximately 2,000 |
| Storage conditions | 4°C to 25°C |
| Use by | Stable for 24 months from date of manufacture |
| Indication | Research Use Only |
Ki-67 Standardization Array
| Catalog Number | Ki-67-18-1-3-1 | Ki67-4-1-3-1 | Ki67-6-1-3-1 |
|---|---|---|---|
| Description | Ki-67 Standard 18-core array. 6 samples in triplicate | Ki-67 Standard 4-core array. | Ki67-Standard 6-core array. |
| Core diameter | 1 mm | 1 mm | 1 mm |
| Well depth | 3 mm | 3 mm | 3 mm |
| Estimated yield per block | Up to 450 slides at 3-4 µm | Up to 450 slides at 3-4 µm | Up to 450 slides at 3-4 µm |
| Composition | This Ki-67 sensitivity control is created by mixing Ki-67 positive cells in a stepwise gradient (0%, 5%, 10%, 20%, 30%, and 100%) in a background of Ki-67 negative cells. This product is available with triplicate cores, as well as single cores (Ki-67-6-1-3-1) | This array provides four cell lines with consistent proliferation indices that can help assess the sensitivity of Ki-67 assays. It is designed for use with the Visiopharm Qualitopix platform but may also be used with manual interpretation or other image analysis applications. The array slides may be helpful for initial assay optimization, validation, and daily QC monitoring assay consistency. | This array provides cell lines mixes with consistent proliferation indices that can help assess the sensitivity and reproducibility of Ki-67 assays. The cell mixes consist of highly proliferative Jurkat cells titered into a background of negative cells (Sf9) at known concentrations. The product may be used with manual interpretation or image analysis applications. The array slides may be helpful for initial assay optimization, validation, and daily QC for monitoring assay consistency. |
| Number of cells per core | Approximately 2,000 | Approximately 2,000 | Approximately 2,000 |
| Storage conditions | 4°C to 25°C | 4°C to 25°C | 4°C to 25°C |
| Use by | Stable for 24 months from date of manufacture | Stable for 24 months from date of manufacture | Stable for 24 months from date of manufacture |
| Reference | Aung, T.N., Acs, B., Warrell, J. et al. A new tool for technical standardization of the Ki67 immunohistochemical assay. Mod Pathol 34, 1261–1270 (2021). https://doi.org/10.1038/s41379-021-00745-6 | Aung, T.N., Acs, B., Warrell, J. et al. A new tool for technical standardization of the Ki67 immunohistochemical assay. Mod Pathol 34, 1261–1270 (2021). https://doi.org/10.1038/s41379-021-00745-6 | Aung, T.N., Acs, B., Warrell, J. et al. A new tool for technical standardization of the Ki67 immunohistochemical assay. Mod Pathol 34, 1261–1270 (2021). https://doi.org/10.1038/s41379-021-00745-6 |
| Indication | Research Use Only | Research Use Only | Research Use Only |
PD-L1 Standardization Array
| Catalog Number | PD-L1-5-1-3-1 |
|---|---|
| Description | PD-L1 Standardization Array 5-core |
| Core diameter | 1 mm |
| Well depth | 3 mm |
| Estimated yield per block | Up to 450 slides |
| Composition | Four engineered cell lines with increasing levels of PD-L1 expression (and a wild-type negative parental line) are present in this array and can distinguish sensitivity among multiple PD-L1 assays. This control can help optimize a given assay and monitor drift of sensitivity over time. It can also be useful for intra-day, inter-day, inter-instrument, and inter-operator evaluation. |
| Number of cells per core | Approximately 2,000 |
| Storage conditions | 4°C to 25°C |
| Use by | Stable for 24 months from date of manufacture |
| Indication | Research Use Only |
P53 Cell Line Control
| Catalog Number | P53-3-1-3-1 |
|---|---|
| Description | 3-core cell culture array |
| Core diameter | 1 mm |
| Well depth | 3 mm |
| Estimated yield per block | Up to 450 slides |
| Composition | Core 1: p53 null mutant (negative) |
| Core 2: p53 wild type (weak, partial) | |
| Core 3: p53 missense mutant (strong, diffuse) | |
| Number of cells per core | 1,500-2,000 |
| Storage conditions | 4°C to 25°C |
| Use by | Stable for 24 months from date of manufacture |
| Indication | Research Use Only |
Multiple Biomarker Array
| Catalog Number | MBA-8-1-3-1 |
|---|---|
| Description | Multiple Biomarker Array |
| Core diameter | 1 mm |
| Well depth | 3 mm |
| Estimated yield per block | Up to 450 slides |
| Composition | This control consists of multiple tumor cell lines, including colon, prostate, breast, melanoma, as well as B- and T-cell lymphoma. This array can serve as a control for a wide range of antibody targets and may be helpful in assay optimization, validation and daily QC. |
| Number of cells per core | Approximately 2,000 |
| Storage conditions | 4°C to 25°C |
| Use by | Stable for 24 months from date of manufacture |
| Indication | Research Use Only |
Melanoma/BRAF V600E
| Catalog Number | BRAF 2-1-3-1 |
|---|---|
| Description | Melanoma/BRAF V600E 2-core |
| Core diameter | 1 mm |
| Well depth | 3 mm |
| Estimated yield per block | Up to 450 slides |
| Composition | This control contains a melanoma cell line that shows the BRAF V600E mutation. As such, it also may serve as a control for multiple melanocytic markers, such as S-100, Melan A, HMB45, SOX10, and PRAME, among others. The negative core is a thyroid medullary carcinoma with reactivity for TTF-1, calcitonin, synaptophysin, and villin, among others. A sensitivity control, showing 0%, 3%, 30%, and 100% BRAF V600E-containing cores is sold separately. |
| Number of cells per core | Approximately 2,000 |
| Storage conditions | 4°C to 25°C |
| Use by | Stable for 24 months from date of manufacture |
| Indication | Research Use Only |